Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery.

ABSTRACT: With the technological advances made to expand space exploration, astronauts will spend extended amounts of time in space before returning to Earth. This situation of unloading and reloading influences human physiology, and readaptation to full weight-bearing may significantly impact astronauts' health. On Earth, similar situations can be observed in patients who are bedridden or suffer from sport-related injuries. However, our knowledge of male physiology far exceeds our knowledge of female's, which creates an important gap that needs to be addressed to understand the sex-based differences regarding musculoskeletal adaptation to unloading and reloading, necessary to preserve health of both sexes. Using a ground-based model of total unloading for 14 days and reloading at full weight-bearin

SUBMITTER: Issertine M 

PROVIDER: S-EPMC10881285 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature