Serum lipidomic changes and sex differences in androgenetic alopecia.

ABSTRACT:

Background

Androgenetic alopecia (AGA) is the most common form of hair loss. Studies have suggested a potential link to metabolic disorders, but with conflicting results. To elucidate the lipidomics profile and sex-specific variations in AGA, while exploring correlation between AGA and metabolic syndrome (MetS).

Methods

The AGA patients (n = 83) and healthy controls (n = 84) were collected in the study. The lipid profiles were analyzed using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Serum levels of important factors associated with AGA, namely dihydrotestosterone (DHT), prostaglandin D₂ (PGD₂) and transforming growth factor-β1 (TGF-β1) were quantified using ELISA.

Results

Compared with controls, AGA pati

SUBMITTER: Wang S 

PROVIDER: S-EPMC10881354 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature