Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor.

ABSTRACT: Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ structures and functions. They are useful for drug testing and serve as active grafts for organ repair. However, organoid construction requires extracellular matrix-like 3D scaffolds for cellular growth. Hydrogel microspheres, with tunable physical and chemical properties, show promise in cartilage tissue engineering by replicating the natural microenvironment. Building on prior work on SF-DNA dual-network hydrogels for cartilage regeneration,

SUBMITTER: Shen C 

PROVIDER: S-EPMC10881360 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature