Engineered M2 macrophage-derived extracellular vesicles with platelet membrane fusion for targeted therapy of atherosclerosis.

ABSTRACT: Atherosclerosis is featured as chronic low-grade inflammation in the arteries, which leads to the formation of plaques rich in lipids. M2 macrophage-derived extracellular vesicles (M₂EV) have significant potential for anti-atherosclerotic therapy. However, their therapeutic effectiveness has been hindered by their limited targeting capability in vivo. The objective of this study was to create the P-M₂EV (platelet membrane-modified M₂EV) using the membrane fusion technique in order to imitate the interaction between platelets and macrophages. P-M₂EV exhibited excellent physicochemical properties, and microRNA (miRNA)-sequencing revealed that the extrusion process had no detrimental effects on miRNAs carried by the nanocarriers. Remarkably,

SUBMITTER: Xie L 

PROVIDER: S-EPMC10881364 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature