Ginkgo biloba extract alleviates CCl₄-induced acute liver injury by regulating PI3K/AKT signaling pathway.

ABSTRACT: Acute liver injury (ALI) is a global health problem associated with high mortality and has attracted clinical attention. Ginkgo biloba extract (GBE) is an extract from dried Ginkgo leaves that has many pharmacological effects because of its various ingredients and has been shown to be hepatoprotective. We investigated the hepatoprotective effect of GBE on carbon tetrachloride (CCl₄)-induced acute liver injury in vitro. The components of Ginkgo biloba extract are analyzed by LC-MS, and the key targets of "liver injury-Ginkgo biloba" are identified based on bioinformatics analysis. The signaling pathways such as PI3K/AKT are mainly enriched with high correlation in KEGG. The results of in vitro experiments showed that compared with the Model group, except that the ALT activity lev

SUBMITTER: Pu X 

PROVIDER: S-EPMC10881365 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature