Smoking changes adaptive immunity with persistent effects.

ABSTRACT: Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability^1-6. However, the variables that drive such differences in cytokine secretion-a crucial component of the host response to immune challenges-remain poorly defined. Here we investigated 136 variables and identified smoking, cytomegalovirus latent infection and body mass index as major contributors to variability in cytokine response, with effects of comparable magnitudes with age, sex and genetics. We find that smoking influences both innate and adaptive immune responses. Notably, its effect on innate responses is quickly lost after smoking cessation and is specifically associated with plasma levels of CEACAM6, whereas its effect on adaptive respons

SUBMITTER: Saint-Andre V 

PROVIDER: S-EPMC10881394 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature