Associations of comorbid substance use disorders with clinical outcomes in schizophrenia using electronic health record data.

ABSTRACT:

Background and hypothesis

Schizophrenia and comorbid substance use disorders (SUDs) are associated with poor treatment outcomes but differences between the associations of different SUDs with clinical outcomes are poorly characterized. This study examines the associations of comorbid SUDs with clinical outcomes in schizophrenia using a largescale electronic health record (EHR) database.

Design

Real-world data (RWD) analysis using the NeuroBlu database; de-identified EHR data were analysed. Multivariable logistic regression, Poisson and CoxPH models were used to compare the associations of specific comorbid SUDs with outcome variables.

Results

Comorbid SUD was significantly different on all outcome measures compared to no SUD (U = 1.44e⁷-1.81e⁷, a

SUBMITTER: Patel R 

PROVIDER: S-EPMC10881404 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature