The association between polymorphism of LDL-R gene and ischemic stroke risk in Chinese population: A meta-analysis.

ABSTRACT:

Objective

Low-density lipoprotein receptor (LDL-R) gene polymorphisms have been indicated to be correlated with ischemic cerebrovascular disease including ischemic stroke susceptibility. However, the results from each published study are inconsistent.

Methods

All eligible case-control studies that met the search terms were retrieved in PubMed, Embase, Wanfang Med Online and Chinese National Knowledge Infrastructure (CNKI) databases. We identified seven independent case-control studies with a total of 10,355 subjects from Chinese population up to May 2023. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility of ischemic stroke.

Results

Meta-analysis results indicated that rs1122608 polymorphism of LDL-R gene significantl

SUBMITTER: Dai Z 

PROVIDER: S-EPMC10881424 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature