The plasmidome associated with Gram-negative bloodstream infections: A large-scale observational study using complete plasmid assemblies.

ABSTRACT: Plasmids carry genes conferring antimicrobial resistance and other clinically important traits, and contribute to the rapid dissemination of such genes. Previous studies using complete plasmid assemblies, which are essential for reliable inference, have been small and/or limited to plasmids carrying antimicrobial resistance genes (ARGs). In this study, we sequenced 1,880 complete plasmids from 738 isolates from bloodstream infections in Oxfordshire, UK. The bacteria had been originally isolated in 2009 (194 isolates) and 2018 (368 isolates), plus a stratified selection from intervening years (176 isolates). We demonstrate that plasmids are largely, but not entirely, constrained to a single host species, although there is substantial overlap between species of plasmid gene-repertoire. Most

SUBMITTER: Lipworth S 

PROVIDER: S-EPMC10881496 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature