Phenotypic and genomic characteristics of clinical IMP-producing Klebsiella spp. Isolates in China.

ABSTRACT:

Background

IMP-producing Klebsiella spp. (IMPKsp) strains have spread globally, including in China. Currently, the prevalence and genomic characterization of IMPKsp is largely unknown nationwide. Here we aimed to provide a general overview of the phenotypic and genomic characteristics of IMPKsp strains.

Methods

61 IMPKsp strains were obtained from 13 provinces in China during 2016-2021. All strains were tested for their susceptibility to antimicrobial agents by the microdilution broth method and sequenced with Illumina next-generation sequencing. We performed conjugation experiments on thirteen representative strains which were also sequenced by Oxford nanopore sequencing technology to characterize bla_IMP-encoding plasmids.

Results

We find that all IMPKsp s

SUBMITTER: Liu C 

PROVIDER: S-EPMC10881498 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature