Association between Charlson comorbidity index and survival outcomes in patients with prostate cancer: A meta-analysis.

ABSTRACT:

Objective

This meta-analysis aimed to assess the influence of comorbidity, as assessed by the Charlson comorbidity index (CCI), on survival outcomes in patients with prostate cancer (PCa).

Methods

We conducted a comprehensive search of the PubMed, Web of Science, and Embase databases to identify studies that examined the association between CCI-defined comorbidity and survival outcomes in PCa patients. We employed a random effect model to merge adjusted hazard ratios (HR) with 95 % confidence intervals (CI) for survival outcomes.

Results

Sixteen studies reporting on 17 articles, which collectively included 457,256 patients. For the presence (CCI score ≥1) versus absence (CCI score of 0) of comorbidity, the pooled HR was 1.59 (95 % CI 1.43-1.77) for all-cause mortality

SUBMITTER: Cui F 

PROVIDER: S-EPMC10881549 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature