Causal relationship between psychological factors and hepatocellular carcinoma as revealed by Mendelian randomization.

ABSTRACT:

Purpose

The impact of psychological factors on the incidence of hepatocellular carcinoma (HCC) in humans remains unclear. Mendelian randomization (MR) study is a novel approach aimed at unbiased detection of causal effects. Therefore, we conducted a two-sample MR to determine if there is a causal relationship between psychological distress (PD), participation in leisure/social activities of religious groups (LARG), and HCC.

Methods

The genetic summary data of exposures and outcome were retrieved from genome-wide association studies (GWAS). We used PD and LARG as exposures and HCC as outcome. Five MR methods were used to investigate the causal relationship between PD, LARG, and HCC. The result of inverse variance weighted (IVW) method was deemed as principal result. Besides,

SUBMITTER: Xu F 

PROVIDER: S-EPMC10881603 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature