Immunophenotyping of peripheral blood in NSCLC patients discriminates responders to immune checkpoint inhibitors.

ABSTRACT:

Purpose

Immune checkpoint inhibitors (ICIs) dramatically changed the prognosis of patients with NSCLC. Unfortunately, a reliable predictive biomarker is still missing. Commonly used biomarkers, such as PD-L1, MSI, or TMB, are not quite accurate in predicting ICI efficacy.

Methods

In this prospective observational cohort study, we investigated the predictive role of erythrocytes, thrombocytes, innate and adaptive immune cells, complement proteins (C3, C4), and cytokines from peripheral blood of 224 patients with stage III/IV NSCLC treated with ICI alone (pembrolizumab, nivolumab, and atezolizumab) or in combination (nivolumab + ipilimumab) with chemotherapy. These values were analyzed for associations with the response to the treatment and survival endpoints.

Results

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SUBMITTER: Krizova L 

PROVIDER: S-EPMC10881622 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature