Head-to-head comparison of [¹¹C]methionine PET, [¹¹C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism.

ABSTRACT:

Purpose

Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [¹¹C]methionine PET/CT, [¹¹C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.

Methods

We conducted a powered, prospective, blinded cohort study in patients with biochemically proven pHPT and prior negative or discordant first-line imaging consisting of ultrasonography and ^99mTc-sestamibi. All patients underwent [¹¹C]methionine PET/CT, [¹¹C]ch

SUBMITTER: Noltes ME 

PROVIDER: S-EPMC10881780 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature