Mitochondrial genetic variation and risk of chronic kidney disease and acute kidney injury in UK Biobank participants.

ABSTRACT: Experimental models suggest an important role for mitochondrial dysfunction in the pathogenesis of chronic kidney disease (CKD) and acute kidney injury (AKI), but little is known regarding the impact of common mitochondrial genetic variation on kidney health. We sought to evaluate associations of inherited mitochondrial DNA (mtDNA) variation with risk of CKD and AKI in a large population-based cohort. We categorized UK Biobank participants who self-identified as white into eight distinct mtDNA haplotypes, which were previously identified based on their associations with phenotypes associated with mitochondrial DNA copy number, a measure of mitochondrial function. We used linear and logistic regression models to evaluate associations of these mtDNA haplotypes with estimated glomerular filtr

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC10881785 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature