CD34⁺DNAM-1^brightCXCR4⁺ haemopoietic precursors circulate after chemotherapy, seed lung tissue and generate functional innate-like T cells and NK cells.

ABSTRACT:

Background

There is little information on the trajectory and developmental fate of Lin^-CD34⁺DNAM-1^bright CXCR4⁺ progenitors exiting bone marrow during systemic inflammation.

Objective

To study Lin^-CD34⁺DNAM-1^bright CXCR4⁺ cell circulation in cancer patients, to characterize their entry into involved lung tissue and to characterize their progenies.

Methods

Flow cytometric analysis of PBMC from 18 patients with lung cancer on samples collected immediately before the first and the second treatment was performed to study Lin^-CD34⁺DNAM-1^bright CXCR4⁺ precursors. Precursors were purified (>99%) and cultured in vitro from all patients. Pa

SUBMITTER: Perrone C 

PROVIDER: S-EPMC10881815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature