Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions.

ABSTRACT: Oxidative post-translational modifications of protein thiols are well recognized as a readily occurring alteration of proteins, which can modify their function and thus control cellular processes. The development of techniques enabling the site-specific assessment of protein thiol oxidation on a proteome-wide scale significantly expanded the number of known oxidation-sensitive protein thiols. However, lacking behind are large-scale data on the redox state of proteins during ageing, a physiological process accompanied by increased levels of endogenous oxidants. Here, we present the landscape of protein thiol oxidation in chronologically aged wild-type Saccharomyces cerevisiae in a time-dependent manner. Our data determine early-oxidation targets in key biological processes governing

SUBMITTER: Jonak K 

PROVIDER: S-EPMC10881836 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature