Causal association between the peripheral immunity and the risk and disease severity of multiple sclerosis.

ABSTRACT:

Background

Growing evidence links immunological responses to Multiple sclerosis (MS), but specific immune factors are still unclear.

Methods

Mendelian randomization (MR) was performed to investigate the association between peripheral hematological traits, MS risk, and its severity. Then, further subgroup analysis of immune counts and circulating cytokines and growth factors were performed.

Results

MR revealed higher white blood cell count (OR [95%CI] = 1.26 [1.10,1.44], P = 1.12E-03, P adjust = 3.35E-03) and lymphocyte count (OR [95%CI] = 1.31 [1.15,1.50], P = 5.37E-05, P adjust = 3.22E-04) increased the risk of MS. In further analysis, higher T cell absolute count (OR [95%CI] = 2.04 [1.36,3.08], P = 6.37E-04, P adjust = 2.19E-02) and CD4⁺ T cell absolute c

SUBMITTER: Chen L 

PROVIDER: S-EPMC10881847 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature