Elevated hyaluronic acid levels in severe SARS-CoV-2 infection in the post-COVID-19 era.

ABSTRACT:

Objective

Human identical sequences of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promoted the coronavirus disease 2019 (COVID-19) progression by upregulating hyaluronic acid (HA) via NamiRNA-enhancer network, based on previous experimental research. This study aimed to investigate the predictive value of HA for the severity of SARS-CoV-2 infection in the post-COVID-19 era.

Methods

A total of 217 consecutive patients with COVID-19 were enrolled at Beijing Ditan Hospital between July 2023 and October 2023. HA levels were analyzed using biochemical detector. Logistic regression analysis was used to screen independent factors for severe COVID-19. The predictive performance of HA for severe infection was assessed by ROC curve. Furthermore, the relationship betw

SUBMITTER: Li Y 

PROVIDER: S-EPMC10881864 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature