Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny.

ABSTRACT: The maternal nutritional environment can impact progeny development, stress tolerance, and longevity. Such phenotypic variation of offspring resulting from the maternal environment is often referred to as the 'maternal effect' and is observed across taxa, including in humans. While some mechanisms behind maternal effects have been revealed, such as histone modification, many studies rely on drastic genetic or nutritional manipulation in describing these mechanisms. Here we aimed to reveal how the maternal environment is regulated under physiological conditions to affect the progeny. Specifically, we detailed metabolic regulation in oocytes in response to mating using Drosophila melanogaster fruit flies. Using liquid chromatography-mass spectrometry, we found that upon mating, the ovary met

SUBMITTER: Hikawa N 

PROVIDER: S-EPMC10882137 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature