Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophrenia.

ABSTRACT:

Background

Schizophrenia (SCZ) is a prevalent and serious mental disorder, and the exact pathophysiology of this condition is not fully understood. In previous studies, it has been proven that ferroprotein levels are high in SCZ. It has also been shown that this inflammatory response may modify fibromodulin. Accumulating evidence indicates a strong link between metabolism and ferroptosis. Therefore, the present study aims to identify ferroptosis-linked hub genes to further investigate the role that ferroptosis plays in the development of SCZ.

Material and methods

From the GEO database, four microarray data sets on SCZ (GSE53987, GSE38481, GSE18312, and GSE38484) and ferroptosis-linked genes were extracted. Using the prefrontal cortex expression matrix of SCZ patients and hea

SUBMITTER: Lian K 

PROVIDER: S-EPMC10882140 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature