Chronic obstructive pulmonary disease trajectory: severe exacerbations and dynamic change in health-related quality of life.

ABSTRACT:

Background

The life trajectory of chronic obstructive pulmonary disease (COPD) remains unknown.

Patients and methods

We collected data from two populations. In the first cohort, we recruited 375 patients with COPD from our hospital, and 1440 repeated assessments of quality of life (QoL) using the European Quality of Life-5 Dimensions questionnaire from 2006 to 2020. We analysed their dynamic changes using the kernel-smoothing method. The second cohort comprised 27 437 patients from the National Health Insurance (NHI) dataset with their first severe acute exacerbations (AEs) requiring hospitalisation from 2008 to 2017 were analysed for their long-term course of AEs. We employed a Cox hazard model to analyse the predictors for mortality or AEs.

Results

Cohorts from our

SUBMITTER: Tsai SH 

PROVIDER: S-EPMC10882291 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature