Randomised, blinded, cross-over evaluation of the palatability of and preference for different potassium binders in participants with chronic hyperkalaemia in the USA, Canada and Europe: the APPETIZE study.

ABSTRACT:

Objectives

Traditional potassium (K⁺) binders for treating hyperkalaemia are unpalatable and poorly tolerated. Newer K⁺ binders are reportedly better tolerated; however, no published data describe their palatability, a determinant of long-term adherence. This study evaluated the palatability of and preference for three K⁺ binders: sodium and calcium polystyrene sulfonate (S/CPS), sodium zirconium cyclosilicate (SZC) and calcium patiromer sorbitex (patiromer).

Design

Phase 4, randomised, participant-blinded, cross-over study. Participants were randomised to one of six taste sequences and, using a 'sip and spit' approach, tasted each K⁺ binder before completing a survey.

Setting

17 centres across the USA, Canada and European U

SUBMITTER: Wheeler DC 

PROVIDER: S-EPMC10882352 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature