The Impact of High or Low Doses of Nicotine in a Mouse Model of Vapor Self-Administration.

ABSTRACT:

Introduction

A wide variety of nicotine concentrations and formulations are available to users of electronic nicotine delivery systems (ENDS). This is increasingly true when considering the many flavors available with ENDS products. To date, there have been few preclinical investigations into the impact of nicotine doses, with and without flavors, on vaping-related behaviors. This present study evaluated how nicotine concentrations relevant to tank-based and pod-based ENDS, with and without flavors, impact reinforcement-related behavior in a mouse model.

Aims and methods

Adult male and female C57/BL6J mice were used in vapor-inhalation self-administration assays. Mice were assigned e-liquids containing 6 mg/mL or 60 mg/mL nicotine. Additional mice were assigned these nicotin

SUBMITTER: Cooper SY 

PROVIDER: S-EPMC10882436 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature