Telechelic sequence-defined oligoamides: their step-economical synthesis, depolymerization and use in polymer networks.

ABSTRACT: The application of sequence-defined macromolecules in material science remains largely unexplored due to their challenging, low yielding and time-consuming synthesis. This work first describes a step-economical method for synthesizing unnatural sequence-defined oligoamides through fluorenylmethyloxycarbonyl chemistry. The use of a monodisperse soluble support enables homogeneous reactions at elevated temperature (up to 65 °C), leading to rapid coupling times (<10 min) and improved synthesis protocols. Moreover, a one-pot procedure for the two involved iterative steps is demonstrated via an intermediate quenching step, eliminating the need for in-between purification. The protocol is optimized using γ-aminobutyric acid (GABA) as initial amino acid, and the unique ability of the resul

SUBMITTER: De Franceschi I 

PROVIDER: S-EPMC10882489 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature