Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model.

ABSTRACT:

Introduction

Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE antibodies targeting galactose-α-1,3-galactose (α-gal), a carbohydrate found in red meat. This condition has gained significant attention globally due to its increasing prevalence, with more than 450,000 cases estimated just in the United States alone. Previous research has established a connection between AGS and tick bites, which sensitize individuals to α-gal antigens and elevate the levels of specific IgE. However, the precise mechanism by which tick bites influence the host's immune system and contribute to the development of AGS remains poorly understood. This study investigates various factors related to ticks and the host associated with the development of AGS following a tick bite, usi

SUBMITTER: Sharma SR 

PROVIDER: S-EPMC10882631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature