Association of demographic and health characteristics with circulating oxysterol concentrations.

ABSTRACT:

Backgound

Circulating oxysterols, cholesterol metabolites with important signaling functions, are increasingly being recognized as candidate biomarkers for several diseases, but associations with demographic and health characteristics remain poorly described.

Objective

This study aims to characterize associations of major circulating oxysterols with sex, age, race/ethnicity, body mass index (BMI), lifestyle factors, and use of common medications.

Methods

We measured plasma concentrations of 27-hydroxycholesterol (27-OHC), 25-hydroxycholesterol (25-OHC), 24(S)-hydroxycholesterol (24(S)-OHC), 7ɑ-hydroxycholesterol (7ɑ-OHC), and 4β-hydroxycholesterol (4β-OHC) from 1,440 participants of a completed clinical trial for the chemoprevention of colorectal adenomas. Adjusted pe

SUBMITTER: Passarelli MN 

PROVIDER: S-EPMC10882644 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature