Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA.

ABSTRACT:

Background

Post-traumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. Available pharmacotherapies are limited, take weeks to show modest benefit and remain ineffective for up to 40% of patients. Methylone is currently in clinical development for the treatment of PTSD. Preclinical studies show rapid, robust and long-lasting antidepressant-like and anxiolytic effects. The mechanism of action underlying these effects is not yet fully understood. This study investigated the downstream gene expression changes and signaling pathways affected by methylone in key brain areas linked to PTSD and MDD. It also sought to determine whether neuroplasticity-related genes were involved. We compared effects of methyl

SUBMITTER: Warner-Schmidt J 

PROVIDER: S-EPMC10882719 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature