Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease.

ABSTRACT:

Background

Neuroinflammation substantially contributes to the pathology of Alzheimer's disease (AD), the most common form of dementia. Studies have reported that nuclear factor erythroid 2-related factor 2 (Nrf2) attenuates neuroinflammation in the mouse models of neurodegenerative diseases, however, the detailed mechanism remains unclear.

Methods

The effects of dimethyl fumarate (DMF), a clinically used drug to activate the Nrf2 pathway, on neuroinflammation were analyzed in primary astrocytes and App^NL-G-F (App-KI) mice. The cognitive function and behavior of DMF-administrated App-KI mice were evaluated. For the gene expression analysis, microglia and astrocytes were directly isolated from the mouse cerebral cortex by magnetic-activated cell sorting, followed by

SUBMITTER: Wang T 

PROVIDER: S-EPMC10882778 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature