A scan for positively selected genes in the genomes of humans and chimpanzees.

ABSTRACT: Since the divergence of humans and chimpanzees about 5 million years ago, these species have undergone a remarkable evolution with drastic divergence in anatomy and cognitive abilities. At the molecular level, despite the small overall magnitude of DNA sequence divergence, we might expect such evolutionary changes to leave a noticeable signature throughout the genome. We here compare 13,731 annotated genes from humans to their chimpanzee orthologs to identify genes that show evidence of positive selection. Many of the genes that present a signature of positive selection tend to be involved in sensory perception or immune defenses. However, the group of genes that show the strongest evidence for positive selection also includes a surprising number of genes involved in tumor suppression and

SUBMITTER: Nielsen R 

PROVIDER: S-EPMC1088278 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature