CD73 mitigates ZEB1 expression in papillary thyroid carcinoma.

ABSTRACT:

Background

ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression and activity of CD73, an ectonucleotidase implicated in adenosine generation, is an important marker of tumor malignancy. Growing evidence suggests that EMT and the adenosinergic pathway are intricately linked and play a pivotal role in cancer development. Therefore, this study focuses on exploring the correlations between CD73 and ZEB1, considering their impact on tumor progression.

Methods

We employed CRISPR/Cas9 technology to silence CD73 expression in cell lines derived from papillary thyroid carcinoma. These same cells underwent

SUBMITTER: Vedovatto S 

PROVIDER: S-EPMC10882796 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature