Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice.

ABSTRACT:

Background

Atherosclerosis(AS) poses a pressing challenge in contemporary medicine. Formononetin (FMN) plays a crucial role in its prevention and treatment. However, the detailed impact of FMN on the stability of atherosclerotic plaques and its underlying mechanisms remain to be elucidated.

Methods

An intervention consisting of FMN was given along with a high-fat food regimen in the ApoE-/- mouse model. The investigation included the evaluation of the degree of atherosclerotic lesion, the main components of the plaque, lipid profiles, particular markers indicating M1/M2 macrophage phenotypes, the quantities of factors related to inflammation, the infiltration of macrophages, and the identification of markers linked to the α7nAChR/JAK2/STAT3 axis effect molecules.

Results<

SUBMITTER: He Y 

PROVIDER: S-EPMC10882812 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature