LncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.

ABSTRACT:

Background

Ischemic stroke (IS) is a common and serious neurological condition that is highly fatal but so far no early diagnostic markers are available. Myocardial infarction-associated transcript (MIAT) is a long non-coding RNA (lncRNA) that could lead to IS by inducing autophagy and apoptosis in neuronal cells. However, there has been no report on the link between susceptibility to IS and the single-nucleotide polymorphisms (SNPs) of MIAT. This study aimed to investigate the association between MIAT gene polymorphisms and IS risk.

Methods

A total of 320 IS patients and 310 age-, sex- and race-matched controls were included in this study. Four polymorphisms (rs2157598, rs5761664, rs1894720, and rs9625066) were genotyped by using SNPscan technique.

Results

Among the

SUBMITTER: Weng YH 

PROVIDER: S-EPMC10882908 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature