Recurrence of macular edema in patients with branch retinal vein occlusion: a proteomic study.

ABSTRACT:

Background

Branch retinal vein occlusion (BRVO) is a common retinal vascular disease leading to severe vision loss and blindness. This study aimed to investigate and reveal the pathophysiological mechanisms underlying macular edema (ME) recurrence in patients with BRVO through a proteomic approach.

Methods

We detected proteins in the aqueous humor of 14 untreated, four refractory, and four post-operative patients with BRVO-ME and 12 age-matched cataract controls using four-dimensional label-free proteomic and bioinformatics analyses.

Results

In total, 84 proteins exhibited significant differential expression between the BRVO and control samples (fold change [FC] ≥ 1.2 and adjusted p-value < 0.05). Compared to the control group, 43 and 41 proteins were upregulated and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10882909 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature