Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9.

ABSTRACT:

Background

Heart failure (HF) is a prevalent clinical syndrome with diverse etiologies. It is crucial to identify novel therapeutic targets based on underlying causes. Here, we aimed to use proteome-wide Mendelian randomization (MR) analyses to identify the associations between genetically predicted elevated levels of circulating proteins and distinct HF outcomes, along with specific HF etiologies.

Methods

Protein quantitative trait loci (pQTL) data for circulating proteins were sourced from the Atherosclerosis Risk in Communities (ARIC) study, encompassing 7,213 individuals and profiling 4,657 circulating proteins. Genetic associations for outcomes were obtained from the HERMES Consortium and the FinnGen Consortium. Colocalization analysis was employed to assess the impact

SUBMITTER: Lin L 

PROVIDER: S-EPMC10882912 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature