Immune checkpoint ligands expressed on mature high endothelial venules predict poor prognosis of NSCLC: have a relationship with CD8⁺ T lymphocytes infiltration.

ABSTRACT:

Background

An insufficient number of intratumoral CD8⁺ T lymphocytes is a major barrier to antitumor immunity and immunotherapy. High endothelial venules (HEVs) are the major sites through which lymphocytes enter tumors; however, the molecular mechanism through which HEVs mediate CD8⁺ T lymphocyte infiltration remains poorly understood.

Methods

Forty-two patients with stage IIIA lung adenocarcinoma, who underwent surgery, were recruited. Multiplex immunohistochemical staining was conducted on tumor tissues to detect the immune checkpoint ligands (ICLs) expressed in the HEVs, blood vessels, and lymphatics. A new ICL score model was constructed to evaluate ligand expression. The relationship between ICL score, tumor-infiltrating CD8⁺ T cell fre

SUBMITTER: Luo J 

PROVIDER: S-EPMC10882939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature