The associations between polygenic risk, sensation seeking, social support, and alcohol use in adulthood.

ABSTRACT: Genetic predispositions play an important role in alcohol use. Understanding the psychosocial mechanisms through which genetic risk unfolds to influence alcohol use outcomes is critical for identifying modifiable targets and developing prevention and intervention efforts. In this study, we examined the role of sensation seeking and social support from family and friends in linking genetic risk to alcohol use. We also examined the role of social support in moderating the associations between genetic risk and sensation seeking and alcohol use. Data were drawn from a sample of 2,836 European American adults from the Collaborative Study on the Genetics of Alcoholism (46% male, mean age = 35.65, standard deviation [SD] = 10.78). Results from path analysis indicated that genome-wide polyg

SUBMITTER: Su J 

PROVIDER: S-EPMC10882995 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature