Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice.

ABSTRACT:

Aims

Disturbances in the circadian rhythm are positively correlated with the processes of aging and related neurodegenerative diseases, which are also associated with brain iron accumulation. However, the role of brain iron in regulating the biological rhythm is poorly understood. In this study, we investigated the impact of brain iron levels on the spontaneous locomotor activity of mice with altered brain iron levels and further explored the potential mechanisms governing these effects in vitro.

Results

Our results revealed that conditional knockout of ferroportin 1 (Fpn1) in cerebral microvascular endothelial cells led to brain iron deficiency, subsequently resulting in enhanced locomotor activity and increased expression of clock genes, including the circadian locomotor o

SUBMITTER: Wu Q 

PROVIDER: S-EPMC10883092 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature