Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum.

ABSTRACT:

Introduction

Understanding impact of environmental properties on Alzheimer's disease (AD) is paramount. Spatial complexity of one's routinely navigated environment is an important but understudied factor.

Methods

A total of 660 older adults from National Alzheimer's Coordinating Center (NACC) dataset were geolocated and environmental complexity index derived from geospatial network landmarks and points-of-interest. Latent models tested mediation of spatial navigation-relevant brain volumes and diagnosis (cognitively-healthy, mild cognitive impairment [MCI], AD) on effect of environmental complexity on spatial behavior.

Results

Greater environmental complexity was selectively associated with larger allocentric (but not egocentric) navigation-related brain volumes, less

SUBMITTER: Shin N 

PROVIDER: S-EPMC10883241 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature