Cystic Fibrosis Carrier States Are Associated With More Severe Cases of Bronchiectasis.

ABSTRACT:

Background

People with cystic fibrosis (CF) are at increased risk for bronchiectasis, and several reports suggest that CF carriers may also be at higher risk for developing bronchiectasis. The purpose of this study was to determine if CF carriers are at risk for more severe courses or complications of bronchiectasis.

Methods

Using MarketScan data (2001-2021), we built a cohort consisting of 105 CF carriers with bronchiectasis and 300 083 controls with bronchiectasis but without a CF carrier diagnosis. We evaluated if CF carriers were more likely to be hospitalized for bronchiectasis. In addition, we examined if CF carriers were more likely to be infected with Pseudomonas aeruginosa or nontuberculous mycobacteria (NTM) or to have filled more antibiotic prescriptions. W

SUBMITTER: Miller AC 

PROVIDER: S-EPMC10883289 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature