Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms.

ABSTRACT: Changes in gene expression underlie many pathogenic endpoints including carcinogenesis. Metals, like arsenic, alter gene expression; however, the consequences of co-exposures of metals with other stressors are less understood. Although arsenic acts as a co-carcinogen by enhancing the development of UVR skin cancers, changes in gene expression in arsenic UVR co-carcinogenesis have not been investigated. We performed RNA-sequencing analysis to profile changes in gene expression distinct from arsenic or UVR exposures alone. A large number of differentially expressed genes (DEGs) were identified after arsenic exposure alone, while after UVR exposure alone fewer genes were changed. A distinct increase in the number of DEGs was identified after exposure to combined arsenic and UVR exposure that

SUBMITTER: Speer RM 

PROVIDER: S-EPMC10883297 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature