Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.

ABSTRACT:

Background

Despite establishing an association between gut microbiota and spondyloarthritis (SpA) subtypes, the causal relationship between them remains unclear.

Methods

Gut microbiota data were obtained from the MiBioGen collaboration, and SpA genome-wide association study (GWAS) summary data were obtained from the FinnGen collaboration. We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance-weighted method supplemented with four additional MR methods (MR-Egger, weighted median, simple mode, and weighted mode). Pleiotropy and heterogeneity were also assessed. Reverse MR analysis was used to detect reverse causal relationships.

Results

We identified 23 causal links between specific gut microbiota taxa and SpA levels. Of these, 22 di

SUBMITTER: Tang J 

PROVIDER: S-EPMC10883304 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature