Dataset Information

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning.

ABSTRACT: Delayed cerebral ischemia (DCI) is a complication seen in patients with subarachnoid hemorrhage stroke. It is a major predictor of poor outcomes and is detected late. Machine learning models are shown to be useful for early detection, however training such models suffers from small sample sizes due to rarity of the condition. Here we propose a Federated Learning approach to train a DCI classifier across three institutions to overcome challenges of sharing data across hospitals. We developed a framework for federated feature selection and built a federated ensemble classifier. We compared the performance of FL model to that obtained by training separate models at each site. FL significantly improved performance at only two sites. We found that this was due to feature distribution differences across sites. FL improves performance in sites with similar feature distributions, however, FL can worsen performance in sites with heterogeneous distributions. The results highlight both the benefit of FL and the need to assess dataset distribution similarity before conducting FL.

SUBMITTER: Elhussein A

PROVIDER: S-EPMC10883332 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning.

Elhussein Ahmed A Megjhani Murad M Nametz Daniel D Weiss Miriam M Savarraj Jude J Kwon Soon Bin SB Roh David J DJ Agarwal Sachin S Sander Connolly E E Velazquez Angela A Claassen Jan J Choi Huimahn A HA Schubert Gerrit A GA Park Soojin S Gürsoy Gamze G

Proceedings. IEEE International Conference on Bioinformatics and Biomedicine 20231201

Delayed cerebral ischemia (DCI) is a complication seen in patients with subarachnoid hemorrhage stroke. It is a major predictor of poor outcomes and is detected late. Machine learning models are shown to be useful for early detection, however training such models suffers from small sample sizes due to rarity of the condition. Here we propose a Federated Learning approach to train a DCI classifier across three institutions to overcome challenges of sharing data across hospitals. We developed a fr ...[more]

PMID: 38389717

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Project description:Beat-by-beat arrhythmia detection in ambulatory electrocardiogram (ECG) monitoring is critical for the evaluation and prognosis of cardiac arrhythmias, however, it is a highly professional demanding and time-consuming task. Current methods for automatic beat-by-beat arrhythmia detection suffer from poor generalization ability due to the lack of large-sample and finely-annotated (labels are given to each beat) ECG data for model training. In this work, we propose a weakly supervised deep learning framework for arrhythmia detection (WSDL-AD), which permits training a fine-grained (beat-by-beat) arrhythmia detector with the use of large amounts of coarsely annotated ECG data (labels are given to each recording) to improve the generalization ability. In this framework, heartbeat classification and recording classification are integrated into a deep neural network for end-to-end training with only recording labels. Several techniques, including knowledge-based features, masked aggregation, and supervised pre-training, are proposed to improve the accuracy and stability of the heartbeat classification under weak supervision. The developed WSDL-AD model is trained for the detection of ventricular ectopic beats (VEB) and supraventricular ectopic beats (SVEB) on five large-sample and coarsely-annotated datasets and the model performance is evaluated on three independent benchmarks according to the recommendations from the Association for the Advancement of Medical Instrumentation (AAMI). The experimental results show that our method improves the F 1 score of supraventricular ectopic beats detection by 8%-290% and the F1 of ventricular ectopic beats detection by 4%-11% on the benchmarks compared with the state-of-the-art methods of supervised learning. It demonstrates that the WSDL-AD framework can leverage the abundant coarsely-labeled data to achieve a better generalization ability than previous methods while retaining fine detection granularity. Therefore, this framework has a great potential to be used in clinical and telehealth applications. The source code is available at https://github.com/sdnjly/WSDL-AD.

Dataset Information

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning.

Publications

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning.

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