Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.

ABSTRACT: Vacuolar pathogens reside in membrane-bound compartments within host cells. Maintaining the integrity of this compartment is paramount to bacterial survival and replication as it protects against certain host surveillance mechanisms that function to eradicate invading pathogens. Preserving this compartment during bacterial replication requires expansion of the vacuole membrane to accommodate the increasing number of bacteria, and yet, how this is accomplished remains largely unknown. Here, we show that the vacuolar pathogen Legionella pneumophila exploits multiple sources of host cell fatty acids, including inducing host cell fatty acid scavenging pathways, in order to promote expansion of the replication vacuole and bacteria growth. Conversely, when exogenous lipids are limited, the decre

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC10883544 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature