Intracellular signaling in proto-eukaryotes evolves to alleviate regulatory conflicts of endosymbiosis.

ABSTRACT: The complex eukaryotic cell resulted from a merger between simpler prokaryotic cells, yet the role of the mitochondrial endosymbiosis with respect to other eukaryotic innovations has remained under dispute. To investigate how the regulatory challenges associated with the endosymbiotic state impacted genome and network evolution during eukaryogenesis, we study a constructive computational model where two simple cells are forced into an obligate endosymbiosis. Across multiple in silico evolutionary replicates, we observe the emergence of different mechanisms for the coordination of host and symbiont cell cycles, stabilizing the endosymbiotic relationship. In most cases, coordination is implicit, without signaling between host and symbiont. Signaling only evolves when there is leakage of regu

SUBMITTER: von der Dunk SHA 

PROVIDER: S-EPMC10883579 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature