Connectivity increases during spikes and spike-free periods in self-limited epilepsy with centrotemporal spikes.

ABSTRACT:

Objective

To understand the impact of interictal spikes on brain connectivity in patients with Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS).

Methods

Electroencephalograms from 56 consecutive SeLECTS patients were segmented into periods with and without spikes. Connectivity between electrodes was calculated using the weighted phase lag index. To determine if there are chronic alterations in connectivity in SeLECTS, we compared spike-free connectivity to connectivity in 65 matched controls. To understand the acute impact of spikes, we compared connectivity immediately before, during, and after spikes versus baseline, spike-free connectivity. We explored whether behavioral state, spike laterality, or antiseizure medications affected connectivity.

Results

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SUBMITTER: Goad BS 

PROVIDER: S-EPMC10883644 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature