PRRSV-2 viral load in critical non-lymphoid tissues is associated with late gestation fetal compromise.

ABSTRACT: The impact of late gestation PRRSV-2 infection is highly variable within a litter, with a subset of fetuses displaying varying degrees of compromise following infection while others remain viable despite significant systemic viral load. To understand the underlying cause of this variation, we examined the susceptibility, distribution and impact of viral infection within non-lymphoid tissues. Samples of brain, heart, kidney, liver, lung, and skeletal muscle were obtained from fetuses of pregnant gilts at gestation day 86, and the presence and distribution of CD163+ cells within each tissue evaluated via immunohistofluorescence. Equivalent samples were collected from phenotypic extremes representing resistant, resilient and susceptible fetuses at 21 days following infection of pregnant gilts

SUBMITTER: Rudy K 

PROVIDER: S-EPMC10883647 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature