A coherent framework for multiresolution analysis of biological networks with "memory": Ras pathway, cell cycle, and immune system.

ABSTRACT: Various biological processes exhibit characteristics that vary dramatically in response to different input conditions or changes in the history of the process itself. One of the examples studied here, the Ras-PKC-mitogen-activated protein kinase (MAPK) bistable pathway, follows two distinct dynamics (modes) depending on duration and strength of EGF stimulus. Similar examples are found in the behavior of the cell cycle and the immune system. A classification methodology, based on time-frequency analysis, was developed and tested on these systems to understand global behavior of biological processes. Contrary to most traditionally used statistical and spectral methods, our approach captures complex functional relations between parts of the systems in a simple way. The resulting algorithms ar

SUBMITTER: Barbano PE 

PROVIDER: S-EPMC1088370 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature