Delivering Robust Proton-Only Sensing of Hyperpolarized [1,2-¹³C₂]-Pyruvate Using Broad-Spectral-Range Nuclear Magnetic Resonance Pulse Sequences.

ABSTRACT: Hyperpolarized [1-¹³C]pyruvate is the leading hyperpolarized injectable contrast agent and is currently under evaluation in clinical trials for molecular imaging of metabolic diseases, including cardiovascular disease and cancer. One aspect limiting broad scalability of the technique is that hyperpolarized ¹³C MRI requires specialized ¹³C hardware and software that are not generally available on clinical MRI scanners, which employ proton-only detection. Here, we present an approach that uses pulse sequences to transfer ¹³C hyperpolarization to methyl protons for detection of the ¹³C-¹³C pyruvate singlet, employing proton-only excitation and detection only. The new pulse sequences are robust to the B₁ and B_0</

SUBMITTER: Mandzhieva I 

PROVIDER: S-EPMC10883757 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature