Two distinct degenerative types of nigrostriatal dopaminergic neuron in the early stage of parkinsonian disorders.

ABSTRACT:

Introduction

The present study characterized the degeneration of nigrostriatal dopaminergic neurons in the early stages of parkinsonian disorders using integrative neuroimaging analysis with neuromelanin-sensitive MRI and ¹²³I-FP-CIT dopamine transporter (DAT) SPECT.

Methods

Thirty-one, 30, and 29 patients with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS) with abnormal specific binding ratio (SBR) in either hemisphere (mean ± 2SD), and parkinsonism-predominant multiple system atrophy (MSA-P), respectively, were enrolled. Neuromelanin-related contrast (NRC) in the substantia nigra (NRC_SN) and locus coeruleus (NRC_LC) and the SBR of DAT SPECT were measured. All the patients underwent both examinations simultaneously within f

SUBMITTER: Kawazoe T 

PROVIDER: S-EPMC10883825 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature